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The saga of the class of drugs known as COX-2 inhibitors has provided an ongoing glimpse into a number of aspects of the multi-billion dollar pharmaceutical industry.

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While they've protected drug company profits in the meantime, they've also irritated the industry's target market -- both consumers and governments alike -- and have even caused a political reaction in the United States and Europe.

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In the first trial, the drug failed to meet the main goal researchers had set to measure its effectiveness. Celebrex May diminish Levels of conditioning enjoyment Biomarker

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    Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.

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